Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose …
H Benveniste, H Lee, F Ding, Q Sun, E Al-Bizri… - …, 2017 - pubs.asahq.org
Background The glymphatic pathway transports cerebrospinal fluid through the brain,
thereby facilitating waste removal. A unique aspect of this pathway is that its function
depends on the state of consciousness of the brain and is associated with norepinephrine
activity. A current view is that all anesthetics will increase glymphatic transport by inducing
unconsciousness. This view implies that the effect of anesthetics on glymphatic transport
should be independent of their mechanism of action, as long as they induce …
thereby facilitating waste removal. A unique aspect of this pathway is that its function
depends on the state of consciousness of the brain and is associated with norepinephrine
activity. A current view is that all anesthetics will increase glymphatic transport by inducing
unconsciousness. This view implies that the effect of anesthetics on glymphatic transport
should be independent of their mechanism of action, as long as they induce …
